Contributions of the d-serine pathway to schizophrenia

► This review describes the role of the d-serine pathway in schizophrenia pathogenesis. ► Genetic studies associate genes regulating d-serine availability with increased schizophrenia risk. ► Postmortem schizophrenia studies observe abnormalities in d-serine modulatory enzymes. ► In vivo findings report altered levels of endogenous NMDA receptor co-agonist site ligands in schizophrenia. ► Genetic animal models with aberrant NMDA receptor co-agonist site function display schizophrenia-like symptoms.