کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5816555 | 1116146 | 2014 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of total glucosides of paeony on immune regulatory toll-like receptors TLR2 and 4 in the kidney from diabetic rats
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کلمات کلیدی
NF-κBCCL-2TGPNF-κB p65TLRSTZIL-1βeNOSMCP-1ICAM-1MYD88TGF-β1TRIF - Trif بهstreptozotocin - استرپتوزوتوسینinflammation - التهاب( توروم) TIR-domain-containing adapter-inducing interferon-β - اینترفرون-β، باعث القاء آداپتور حاوی دامنه TIR می شودInterleukin-1β - اینترلوکین-1βTransforming growth factor-β1 - تبدیل فاکتور رشد β1tumor necrosis factor-α - تومور نکروز عامل αToll-like receptor - تیالآرendothelial nitric oxide synthase - سنتاز اکسید نیتریک اندوتلیالmyeloid differentiation factor 88 - عامل تمایز میلوئید 88TNF-α - فاکتور نکروز توموری آلفاintercellular adhesion molecule-1 - مولکول چسبندگی بین سلولی -1Diabetic nephropathy - نفروپاتی دیابتیMonocyte chemotactic protein-1 - پروتئین chemotactic monocyte-1Total glucosides of paeony - کل گلوکوزید های پونهToll-like receptors - گیرنده های پولی مانند
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیوشیمی بالینی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
TLRs are a family of receptors that play a critical role in the pathogenesis of diabetic nephropathy. TGP have been shown to have anti-inflammatory and immuno-regulatory activities. However, the relation between TGP and TLRs on diabetic nephropathy remains unknown. In this study, we examined effects of TGP on immune regulatory TLR2 and 4 in the kidney from streptozotocin-induced diabetic rats. TGP decreased the levels of 24 h urinary albumin excretion rate significantly in diabetic rats. Western blot analysis showed that TGP significantly inhibited the expression of TLR2 and 4, MyD88, p-IRAK1, NF-κB p65, p-IRF3, TNF-α and IL-1β. Quantitative real-time PCR analysis showed that the significantly increased levels of TLR2 and 4, and MyD88mRNA in the kidneys of diabetic rats were significantly suppressed by TGP treatment. Macrophages infiltration were also markedly increased in the kidneys of the diabetic rats, but were significantly inhibited by TGP in a dose-dependent manner. These results suggest that TGP has protective effects on several pharmacological targets in the progress of diabetic nephropathy by selectively blocking TLRs activation in vivo.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Phytomedicine - Volume 21, Issue 6, 15 May 2014, Pages 815-823
Journal: Phytomedicine - Volume 21, Issue 6, 15 May 2014, Pages 815-823
نویسندگان
Xing-xin Xu, Xiang-Ming Qi, Wei Zhang, Chao-Qun Zhang, Xiao-Xu Wu, Yong-Gui Wu, Kun Wang, Ji-Jia Shen,