کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5817090 | 1556833 | 2015 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Complement system and immunological mediators: Their involvements in the induced inflammatory process by Androctonus australis hector venom and its toxic components
ترجمه فارسی عنوان
سیستم مکمل و واسطه های ایمنولوژیک: دخالت آنها در روند التهابی القا شده توسط سم آندروکتونوس آستالیالس هکتور و اجزای سمی آن
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کلمات کلیدی
TNFαAndroctonus australis hectorLethal dosesNMRICR1AAHCD55ICAMRBCsGPiRBCLD50MCPLPSRed blood cells - سلولهای قرمز خونIL1β - IL1btumor necrosis factor α - تومور نکروز عامل αcluster of differentiation - خوشه تمایزComplement system - دستگاه کمپلمان، سیستم کمپلمانCytotoxicity - سمیت سلولیlipopolysaccharide - لیپوپلی ساکاریدmembrane cofactor protein - پروتئین کوفتور غشاءComplement receptors - گیرنده های تکمیلی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم دامی و جانورشناسی
چکیده انگلیسی
Androctonus australis hector scorpion venom is well known by its high toxicity, it induces massive release of neurotransmitters that lead to pathophysiological disorders in cardiovascular, neuro-hormonal and immune systems. Previous studies have shown the relationship between the severity of scorpion envenoming and immune system activation. This study was assessed to investigate the involvement of complement system and inflammatory mediators after sublethal injection of Aah venom, its toxic fraction (FtoxG50) and its main toxins (AahI and AahII) into NMRI mice. The Activation complement system by the venom is also compared to that induced of lipoplysaccharides (LPS). Obtained results showed that seric complement system (CS) is activated by the venom and by its toxic components; this activation is more pronounced into liver tissue when toxic components (FtoxG50, AahI or AahII) are used. Increase of cytokine levels (IL1β, TNFα and ICAM) into hepatic tissue induced by AahI or AahII neurotoxins is correlated with tissue alterations. Aprotinin, a non specific inhibitor of complement system seems to be able to reduce CS consumption and to restore partially the induced tissue damage by venom. The mechanisms by which toxic fraction or LPS induced the activation of complement system seem to be different. Sensitivity of hepatic tissue is more pronounced after FtoxG50 injection; however lung tissue is more sensible to LPS than FoxG50.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental and Toxicologic Pathology - Volume 67, Issues 7â8, JulyâAugust 2015, Pages 389-397
Journal: Experimental and Toxicologic Pathology - Volume 67, Issues 7â8, JulyâAugust 2015, Pages 389-397
نویسندگان
Nadjia Bekkari, Marie-France Martin-Eauclaire, Fatima Laraba-Djebari,