ABC50 modulates sensitivity of HL60 leukemic cells to endoplasmic reticulum (ER) stress-induced cell death

ABC50 promotes the association of Met-tRNA with the eIF2 complex. eIF2α represents a key initiation control point. In response to cellular stress of various kinds, eiF2α is phosphorylated by key kinases which suppress translation initiation. ABC50 promotes the association of Met-tRNA with eIF2, enhancing translation.