کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5825961 1558127 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Vascular mineralocorticoid receptor and blood pressure regulation
ترجمه فارسی عنوان
گیرنده های اندوکرکتوئید عروقی و تنظیم فشار خون
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
چکیده انگلیسی
The mineralocorticoid receptor (MR) is a major regulator of blood pressure by modulating sodium balance and blood volume in the distal nephron. The discovery of MR expression in both endothelial and vascular smooth muscle cells a decade ago raised questions about its role in the vascular wall and its involvement in blood pressure regulation. In vitro and in vivo pharmacological studies have shown that vascular MR is involved in several vascular properties such as extracellular matrix remodeling, inflammation and vascular reactivity. In this review, we focus on recent advances obtained using transgenic model with cell-specific modulation of the expression MR in endothelium or smooth muscle and their impact on blood pressure.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Pharmacology - Volume 21, April 2015, Pages 138-144
نویسندگان
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