کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5825977 1558125 2015 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Regulatory plasma cells
ترجمه فارسی عنوان
سلول های پلاسمای تنظیم کننده
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
چکیده انگلیسی
B cells can regulate immunity negatively or positively. Identifying the B cell subsets mediating these antagonistic activities, and the molecular mechanisms governing their differentiation, might enable the development of novel approaches to target B cells therapeutically. The suppressive functions of B cells are primarily mediated through their production of interleukin (IL)-10 and IL-35. Recent studies have shown that distinct sets of IgM+CD19+CD138hi plasma cells were the major B cell subsets producing these cytokines in a regulatory manner in vivo during autoimmune and infectious diseases. This review summarizes current knowledge on these 'regulatory plasma cells', and discusses the emerging data showing that the mechanisms involved in their generation partly overlap with those controlling the differentiation of 'effector regulatory T cells'.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Pharmacology - Volume 23, August 2015, Pages 1-5
نویسندگان
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