Evaluation of presumptive biomarkers of oxidative stress, immune response and apoptosis in primary open-angle glaucoma

► Oxidative stress, immune response and apoptosis in POAG initiation and progression. ► Putative glaucoma biomarkers are MDA, TAS, 8-OH-dG, ILs-1α/6, Cas-2/3/14 and PARP-1. ► Certain antibodies and cytokines vary in relation to POAG in aqueous humor and serum. ► Apoptosis biomarkers from blood and virtually every ocular sample might apply to POAG. ► Advances in biotechnology offer remarkable opportunities for glaucoma research.