کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5826253 1120426 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The gut hormone glucagon-like peptide-1 produced in brain: is this physiologically relevant?
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
The gut hormone glucagon-like peptide-1 produced in brain: is this physiologically relevant?
چکیده انگلیسی
Glucagon-like peptide-1 (GLP-1) is both a peripherally expressed incretin and a centrally active neuropeptide. Brain derived GLP-1, produced in preproglucagon (PPG) neurons located in the nucleus of the solitary tract (NTS) and projecting to numerous brain regions, is ideally placed to activate central GLP-1 receptors in a range of autonomic control areas. In vivo analysis of central GLP-1 using GLP-1 receptor antagonists has demonstrated the control of a range of feeding responses mediated by GLP-1 receptor activation. Recent advances enabling identification and targeting of the neurons in the NTS has specifically implicated PPG neurons at the core of GLP-1 dependent central and peripheral control for short-term and long-term energy balance.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Pharmacology - Volume 13, Issue 6, December 2013, Pages 964-969
نویسندگان
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