The fibroblast as a therapeutic target in rheumatoid arthritis

► Therapies targeting fibroblasts in RA are a certainty. ► These therapies may succeed in treating existing biologic 'non-responders'. ► Fibroblast therapies have the potential to modify disease persistence. ► Novel fibroblast markers developed in cancer and immunology will provide a new generation of specific treatments. ► More specific drugs that do not target leukocytes are likely to cause less bone marrow suppression and infection.