The role of omega-3 derived resolvins in arthritis

► Omega-3 PUFA reduce joint swelling and pain and are NSAID sparing agents in RA. ► Resolvins offer a potential mechanism for the beneficial use of omega-3 PUFA. ► Specific GPCRs convey the biological activities of resolvins. ► Resolvins offer new terrain for developing therapeutics for inflammatory diseases.