Transient receptor potential vanilloid type 1 and pain development

► TRPV1 is activated/sensitized by multiple signals during inflammatory processes. ► TRPV1 phosphorylation reduces its threshold for detecting painful stimuli. ► TRPV1 ligands may alleviate pain at peripheral, spinal and supraspinal level. ► TRPV1 expression in the PAG is a source for inducing antinociception.