Beta blockers, nitric oxide, and cardiovascular disease

► The third generation β-blockers may act in a NO-dependent manner. ► They activate NOS synthases and/or prevent NO synthase uncoupling. ► They preserve NO bioavailability due to their antioxidant properties. ► This leads to vasodilatation, anti-proliferation and cardioprotection. ► These properties confer distinct advantages for treating cardiovascular disease.