Mineralocorticoid receptor antagonists for therapy of coronary artery disease and related complications

► Aldosterone levels predict mortality and/or MACCE in patients with CAD, MI or CHF. ► MR activation induces cardiovascular inflammation, endothelial dysfunction and remodelling. ► MRAs reduce mortality and hospitalization in patients with reduced LV function, CHF or acute MI. ► MRAs are still under-prescribed although prescription is safe under certain precautions.