Control of the immune system by oxysterols and cancer development

► Oxysterols/oxysterol receptors (LXRα and LXRβ isoforms) modulate several immune cells. ► Oxysterols/oxysterol receptors control some immune-based diseases and tumors. ► LXRs act by activating target genes or trans-repressing pro-inflammatory genes. ► Oxysterols can activate some cellular functions in an LXR-independent manner. ► Manipulating LXR-dependent/independent effects for autoimmune diseases and tumors.