On the adaptive nature of Annexin-A1

Studies over the last decade have provided us with a wealth of evidence showing that Annexin-1 is a homeostatic endogenous anti-inflammatory mediator of the innate immune system. However, as in Robert Louis Stevenson's novel 'The Strange Case of Dr Jekyll and Mr Hyde', recent investigations on the role of this protein in the adaptive immune response have revealed a previous unknown 'dark side' as positive modulator of T cell activation. This review will be focusing on these recent findings providing further evidences for the promising therapeutic potential of drugs targeting Annexin-1.