کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5826587 1120451 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The leptin hypothesis of depression: a potential link between mood disorders and obesity?
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
The leptin hypothesis of depression: a potential link between mood disorders and obesity?
چکیده انگلیسی

The adipose-derived hormone leptin is well known for its function in the control of energy homeostasis. Recent studies suggest a novel role for this adipokine in the regulation of mood and emotion. Low levels of leptin have been found to be associated with depressive behaviors in rodents and humans. Pharmacological studies indicate that leptin has antidepressant-like efficacy. Both leptin insufficiency and leptin resistance may contribute to alterations of affective status. Identifying the key brain regions that mediate leptin's antidepressant activity and dissecting its intracellular signal transduction pathways may provide new insights into the pathogenesis of depression and facilitate the development of novel therapeutic strategies for the treatment of this illness.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Pharmacology - Volume 7, Issue 6, December 2007, Pages 648-652
نویسندگان
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