The relationship between the g.27450A>T genetic variant of OPG gene and osteoporosis in Chinese postmenopausal women

- Osteoprotegerin gene (OPG) gene plays an important role in the pathogenesis of osteoporosis.
- The g.27450A>T SNP is associated with spine, neck hip and total hip BMD.
- The OPG gene is related to BMD and osteoporosis in Chinese postmenopausal women.

The objective of this study is to evaluate the relationship between the g.27450A>T genetic variant of osteoprotegerin (OPG) gene and osteoporosis in Chinese postmenopausal women. A total of 886 subjects were enrolled in this study. The femoral neck hip, lumbar spine (L2-4), and total hip bone mineral density (BMD) were detected by dual-energy X-ray absorptiometry (DEXA). The genotyping of the g.27450A>T genetic variant of OPG gene was investigated by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and DNA sequencing methods. Significant differences in the femoral neck hip, lumbar spine (L2-4), and total hip BMD among different genotypes were found, and the subjects with AA genotype were significantly higher than those of AT and TT genotypes (P < 0.05). The allele-A could be a decreased risk factor for osteoporosis. Results from this study support that the g.27450A>T genetic variant of OPG gene has potential relationship with BMD and osteoporosis in Chinese postmenopausal women.