کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5832877 | 1122612 | 2014 | 7 صفحه PDF | دانلود رایگان |

- CD4+CD25+FOXP3Â + and CD8+CD28Â â tregs were Significantly higher in NSCLC than Controls.
- CD4+CD25+FOXP3Â + and CD8+CD28Â â tregs increased with tumor stage and dropped significantly after operation.
- Postoperative tregs in early stage was in the same level of controls while in advanced stage was higher than controls.
Little is known about the regulatory T cells (Tregs) in the peripheral blood after surgery of non-small cell lung cancer (NSCLC) patients. In this study, we investigated whether CD4+CD25+FOXP3 + and CD8+CD28 â regulatory T cells are decreased in the peripheral blood of NSCLC patients undergoing surgery. The study group (n = 49) comprised NSCLC, and the control group (n = 24) consisted of age- and sex-matched nonmalignant diseases. The prevalence of CD4+CD25+FOXP3 + and CD8+CD28 â Tregs was analyzed using flow cytometry. The study group showed significantly higher percentage of CD4+CD25+FOXP3 + and CD8+CD28 â Tregs than control. The percentage of CD4+CD25+FOXP3 + and CD8+CD28 â Tregs increased with tumor stage. One way ANOVA test shows the significant differences between all subgroups. LSD test shows that there was a statistical significance between each of the two subgroups except stage II in CD4+CD25+FOXP3 + Tregs and control vs. each stage, stage I vs. stage III, and stage IV in CD8+CD28 â Tregs. There is no significant difference among stages II, III, and IV in CD8+CD28 â Tregs. No differences were found between squamous carcinoma and adenocarcinoma. These levels were dropped significantly after operation. Furthermore postoperative Treg percentage in the early stages (stage I and stage II) was not statistically different from that of controls. Postoperative Treg percentage in advanced stage (III + IV) remained above the values shown by controls. Our findings indicate that the percentage of CD4+CD25+FOXP3 + and CD8+CD28 â Tregs correlated with the pathological stage in NSCLC and tumor burden.
Journal: International Immunopharmacology - Volume 18, Issue 2, February 2014, Pages 255-261