Lactoferrin moderates LPS-induced hypotensive response and gut injury in rats

► Lactoferrin (LF) was examined to prevent septic events in a LPS-induced hypotension model in rats. ► LF Administration prior to LPS challenge enabled reduced mean arterial pressure (MAP) and reduced hypotensive response. ► Concurrent with reduction in MAP, LF administration allowed homeostasis of serum TNF-α and IL-6, but not TGF-β. ► LF demonstrated protection of proximal duodenal architectural integrity due to hypotensive changes.