Effects of paraoxonase 1 activity and gene polymorphisms on long-term pulmonary complications of sulfur mustard-exposed veterans

► No significant difference in PON1 genotype distributions between the veterans and controls. ► PON1 in veterans with the (RR or QR) + LL genotype was significantly lower than those of the controls. ► Positive correlation was determined between serum PON1 activity and pulmonary function test in QR/LL genotype. ► A novel missense was identified in exon 6, 18256 A to T and 18257 A to C, result Asn to Ser. The Asn227Ser change was detected in 40% of veterans with RR + QR genotypes.