In vitro and in vivo protection provided by pinocembrin against lipopolysaccharide-induced inflammatory responses

► Pinocembrin regulated the expressions of TNF-α, IL-1β, IL-6 and IL-10 in RAW cells. ► Pinocembrin attenuated lipopolysaccharide (LPS)-induced lung inflammation. ► Pinocembrin blocked LPS-induced MAPK and NF-κB activation in lung tissue.