Glycyrrhizin regulates CD4+T cell response during liver fibrogenesis via JNK, ERK and PI3K/AKT pathway

► Glycyrrhizin ameliorates ConA-induced liver inflammation and fibrosis in mice. ► Glycyrrhizin inhibits the infiltration of CD4+T cells in livers. ► Glycyrrhizin regulates CD4+T balance to a relative dominance of Th1 and Treg. ► Glycyrrhizin regulates CD4+T response via JNK, ERK and PI3K/AKT pathways.