A novel tylophorine analog NK-007 ameliorates colitis through inhibition of innate immune response

► NK-007 has treatment effects on DSS-induced and acetic acid-induced colitis. ► NK-007 inhibited TNF-α and IL-12 expression in BMDCs. ► NK-007 reduced TNF-α production in raw 264.7 cells. ► NK-007 ameliorated IBD through decreasing the phosphorylation of p65.