Trigonelline ameliorates diabetic hypertensive nephropathy by suppression of oxidative stress in kidney and reduction in renal cell apoptosis and fibrosis in streptozotocin induced neonatal diabetic (nSTZ) rats

► Trigonelline (TG) is a plant hormone which is claimed to have antidiabetic and hypoglycemic activities. ► Oxidative stress and apoptosis play a central role in diabetic nephropathy. ► TG treatment ameliorates oxidative stress in mononuclear cells. ► Decreased apoptosis in renal cells confirmed the antiapoptotic role of trigonelline. ► Renal histology showed decreased tubular damage and fibrosis after TG treatment.