Lactobacillus johnsonii HY7042 ameliorates Gardnerella vaginalis-induced vaginosis by killing Gardnerella vaginalis and inhibiting NF-κB activation

► Hydrogen peroxide-producing Lactobacillus johnsonii HY7042 inhibited Gardnerella vaginalis-induced vaginosis in mice. ► L. johnsonii killed G. vaginalis in vitro and in vivo. ► L. johnsonii inhibited TNF-α and IL-1β expressions and NF-κB activation in LPS-stimulated macrophages and mouse vaginosis.