کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5833781 1122633 2011 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
ReviewToll-like receptors in inflammation of the central nervous system
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
ReviewToll-like receptors in inflammation of the central nervous system
چکیده انگلیسی

Toll-like receptors (TLRs) belong to pattern-recognition receptor family that could recognize exogenous pathogen-associated molecular patterns and endogenous damage-associated molecular patterns. TLRs play pivotal roles in innate and adaptive immune responses. In this review we summarize the ligands and signal transduction pathways of TLRs and highlight recent progress of the involvement of TLRs in neuroinflammation related disorders, including cerebral ischemia/stroke, brain trauma and hemorrhage, pathogen infection and autoimmune diseases, and explore the potential of TLR signaling as therapeutic targets against these disorders.

► TLRs are involved in in neural injury related inflammation. ► TLRs play important roles in pathogen infection-induced neuroinflammation. ► TLRs are also related to autoimmune diseases in CNS. ► TLRs are potential therapeutic targets against neuroinflammation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Immunopharmacology - Volume 11, Issue 10, October 2011, Pages 1407-1414
نویسندگان
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