Arctigenin induces cell cycle arrest by blocking the phosphorylation of Rb via the modulation of cell cycle regulatory proteins in human gastric cancer cells

► Arctigenin activated the expression of p21 and p15 protein, and down-regulated the expression of cyclin D1, cyclin E, CDK4 and CDK2 ► Arctigenin inhibited hyper-phosphorylation of Rb protein ► Arctigenin induced cell cycle arrest from G1 to S ► Arctigenin activated Bax expression and down-regulated Bcl-2 expression ► Arctigenin induces apoptosis of SNN-1 and AGS cells by blocking hyper-phosphorylation of Rb via regulating the expression of cell cycle-related proteins.