Wogonin induces apoptosis and down-regulates survivin in human breast cancer MCF-7 cells by modulating PI3K-AKT pathway

► Wogonin can induce apoptosis in human breast cancer MCF-7 cells. ► Wogonin induces apoptosis via regulating the expression of bcl-2,Bax, P53 and survivin. ► Both PI3K-AKT and MAPK/ERK pathways play a key role on wogonin induces apoptosis. ► Wogonin down-regulates survivin,a downstream target of the PI3K/AKT pathway. ► The activation of caspase-3 play a important role on wogonin-induced -apoptosis.