Immunomodulatory studies of a bioactive fraction from the fruit of Prunus cerasus in BALB/c mice

► Immunostimulatory potential of PNRS-EtOAC fraction (Prunus cerasus) investigated. ► Augmentation of HA titre and DTH response to sheep red blood cells (SRBC) revealed. ► A significant enhancement of Th1 (IFN-γ and TNF-α) and Th2 (IL-4) immune response. ► Significant enhancement in CD4, CD8, CD80 and CD86 cell populations revealed. ► Important role of PNRS-EtOAC in the modulation of the immune response highlighted.