Arsenic decreases RXRα-dependent transcription of CYP3A and suppresses immune regulators in hepatocytes

► We demonstrate that arsenic affects transcription of CYP3A4 in hepatocytes after 6 h. ► Low nanomolar concentrations of arsenic decrease CYP3A4 levels. ► The proteasome pathway affects RXR-alpha levels in primary human hepatocytes and in the hepatocarcinoma cell line, HepG2.