Skullcapflavone II inhibits ovalbumin-induced airway inflammation in a mouse model of asthma

► Skullcapflavone II, one of the flavonoid from S. baicalensis. ► A murine asthma model was used to investigate the therapeutic effects of skullcapflavone II. ► Skullcapflavone II significantly reduced major pathophysiological features of asthma. ► Anti-asthmatic activities of skullcapflavone II was involved the TGF-β1/Smad pathway. ► Skullcapflavone II may have therapeutic potential for the treatment of allergic asthma.