Evaluation of the impact of Polygonum capitatum, a traditional Chinese herbal medicine, on rat hepatic cytochrome P450 enzymes by using a cocktail of probe drugs

The presented plasma concentration-time profiles of (a) tolbutamide and (b) midazolam in untreated and Polygonum capitatum extract pre-treated rats showed the characteristics of the induction of CYP2C9 and CYP3A4 to varying degrees.89