کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5837409 1123966 2013 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Dose-dependent antihypertensive determination and toxicological studies of tilianin isolated from Agastache mexicana
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Dose-dependent antihypertensive determination and toxicological studies of tilianin isolated from Agastache mexicana
چکیده انگلیسی

Ethnopharmacological relevanceAgastache mexicana is used in Mexican traditional medicine for the treatment of hypertension, anxiety and related diseases.Aim of the studyCurrent work was developed to establish pharmacological/toxicological parameters of tilianin, a flavone extracted from Agastache mexicana in order to propose it for clinical trials.Materials and methodsAcute and sub-acute toxicology studies in Imprinting Control Region (ICR) mice and median effective dose (ED50) determination in conscious spontaneously hypertensive rats (SHR) were done.ResultsA median lethal dose (LD50) of 6624 mg/kg (6201, 7076) in mice and significant antihypertensive effect (ED50=53.51 mg/kg) in SHR were determined. Moreover, sub-acute oral administration of tilianin did not alter body weight, clinical chemistry parameters (alanine amino-transferase, aspartate amino-transferase, total cholesterol, high density lipoprotein, low density lipoprotein, triglycerides, glucose and insulin), and also did not induce any toxic or adverse effects on kidney, heart, liver, and lung functions.ConclusionsWe have shown that tilianin, isolated from Agastache mexicana, was not toxic for rodents. Also, its antihypertensive effect was dose-dependent and ED50 (53.51 mg/kg) calculated was lesser than LD50 determined (6624 mg/kg), which suggest a wide range of pharmacology-toxicology patterns. Results support the hypothesis that tilianin must be investigated and developed for clinical trials as antihypertensive drug.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Ethnopharmacology - Volume 146, Issue 1, 7 March 2013, Pages 187-191
نویسندگان
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