کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5838229 | 1123977 | 2012 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Attenuation of airway hyperreactivity and T helper cell type 2 responses by coumarins from Peucedanum praeruptorum Dunn in a murine model of allergic airway inflammation
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
ESI-MSnPPDOVADADEPOCPPDPeucedanum praeruptorum DunnAsthma - آسمAllergy - آلِرژیeosinophil peroxidase - ائوزینوفیل پراکسیدازUltraviolet - اشعه فرابنفشinflammation - التهاب( توروم) Ovalbumin - اوبلبومینimmunoglobulin - ایمونوگلوبولینinterferon - اینترفرونIFN - اینترفرون هاinterleukin - اینترلوکینBALF - بافتdiode array detection - تشخیص آرایه دیودElectrospray ionization tandem mass spectrometry - طیف سنجی جرمی یونیزه الکترو اسپری یونیزاسیونBronchoalveolar lavage fluid - مایع لارو برونکلوفلورLung resistance - مقاومت ریهhigh performance liquid chromatography - کروماتوگرافی مایع با کارایی بالاHPLC - کروماتوگرافی مایعی کاراCoumarin - کومارین
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Attenuation of airway hyperreactivity and T helper cell type 2 responses by coumarins from Peucedanum praeruptorum Dunn in a murine model of allergic airway inflammation Attenuation of airway hyperreactivity and T helper cell type 2 responses by coumarins from Peucedanum praeruptorum Dunn in a murine model of allergic airway inflammation](/preview/png/5838229.png)
چکیده انگلیسی
Ethnopharmacological relevanceThe root of Peucedanum praeruptorum Dunn (PPD) is a commonly used traditional Chinese medicine for the treatment of asthma. Its major constituents, coumarins, were presumed to be responsible for its efficacy.Aim of the studyThe potential of coumarins from PPD (CPPD) as anti-asthma agent was investigated.Materials and methodsFemale BALB/c mice were sensitized and challenged with ovalbumin (OVA) to induce allergic airway inflammation. CPPD was administered intragastrically before every OVA challenge. Airway reactivity to the intravenous administration of acetylcholine chloride was measured 48 h after final OVA inhalation. Airway inflammation was evaluated by leukocyte counts of bronchoalveolar lavage fluid (BALF) and histopathological analysis of lung lesions. Levels of interleukin (IL)-4, IL-5, IL-10, IL-13 and IFN-γ in BALF and OVA-specific immunoglobulin (Ig) E in serum, and activity of eosinophil peroxidase (EPO) in lung was measured. The percentage of CD4+CD25+Foxp3+ regulatory T cells among CD4+ T cells in spleen was analyzed by flow cytometry.ResultsCompared with model group, CPPD significantly reduced airway hyperreactivity and airway eosinophilic inflammation, improved pathologic lesion of the lungs, reduced levels of IL-4, IL-5, IL-13 in BALF and OVA-specific IgE in serum, inhibited the activities of EPO in lung, and up-regulated levels of IL-10 and IFN-γ in BALF as well as the percentage of CD4+CD25+Foxp3+ regulatory T cells in spleen.ConclusionCPPD can significantly suppress OVA-induced airway inflammation, airway hyperreactivity and Th2 predominant response in mice, showing great therapeutic potential for the treatment of allergic asthma.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Ethnopharmacology - Volume 141, Issue 1, 7 May 2012, Pages 314-321
Journal: Journal of Ethnopharmacology - Volume 141, Issue 1, 7 May 2012, Pages 314-321
نویسندگان
You-Yi Xiong, Fei-Hua Wu, Jun-Song Wang, Juan Li, Ling-Yi Kong,