Antinociceptive effect of the essential oil of Zingiber zerumbet in mice: Possible mechanisms

The essential oil of Zingiber zerumbet (EOZZ)-induced antinociceptive activity was possibly related to its ability to inhibit TRPV1 receptors, protein kinase C, glutamatergic system as well as through activation of l-arginine/nitric oxide/cGMP/ATP-sensitive K+ channel pathway.