Anti-inflammatory activities of Chinese herbal medicine sinomenine and Liang Miao San on tumor necrosis factor-α-activated human fibroblast-like synoviocytes in rheumatoid arthritis

► We studied the mechanism for the anti-inflammatory activity of sinomenine and LMS. ► Sinomenine and LMS can suppress TNF-α-induced VCAM-1 and chemokine expression. ► Sinomenine and LMS could suppress TNF-α-induced NF-κB and ERK. ► Sinomenine and LMS can modulate intracellular signaling pathways in FLS to treat RA.