Neuroprotective effects of Eleutherococcus senticosus bark on transient global cerebral ischemia in rats

Oral administration of Eleutherococcus senticosus significantly reduced hippocampal CA1 neuronal death and decrease in spontaneous alternation against global cerebral ischemia in rats. Eleutherococcus senticosus also attenuated ischemia-induced activation of COX-2, astrocyte and microglial in the hippocampal CA1 region.