Lipopolysaccharide increased the acute toxicity of the Rhizoma coptidis extract in mice by increasing the systemic exposure to Rhizoma coptidis alkaloids

Rhizoma coptidis is used as an antidysenteric in clinics in China. The current study investigates the effects of lipopolysaccharide, a key pathogenic factor in dysentery, on the acute toxicity of a Rhizoma coptidis extract in mice; possible mechanisms are proposed.