کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5839420 | 1123993 | 2011 | 6 صفحه PDF | دانلود رایگان |
Ethnopharmacological relevanceThe genus Ocimum (Lamiaceae) has a long history of use as culinary and medicinal herbs. Many species are used for their antioxidant and neuroprotective activity in various parts of the world. Ocimum basilicum Linn. has been used traditionally for the treatment of anxiety, diabetes, cardiovascular diseases, headaches, nerve pain, as anticonvulsant and anti-inflammatory, and used in a variety of neurodegenerative disorders.Aim of the studyThe present study is designed to investigate the effect of ethyl acetate extract of Ocimum basilicum leaves on ischemia and reperfusion-induced cerebral damage, and motor dysfunctions in mice.Materials and methodsGlobal cerebral ischemia was induced by bilateral carotid artery occlusion for 15Â min followed by reperfusion for 24Â h. Cerebral infarct size was measured using triphenyltetrazolium chloride staining. The concentration of thiobarbituric acid reactive substances (TBARS) and reduced glutathione (GSH) content was determined by colorimetric assay. Short-term memory was evaluated using elevated plus-maze. Inclined beam walking was employed to assess motor coordination. Bilateral carotid artery occlusion followed by reperfusion produced significant increase in cerebral infarct size and lipid peroxidation (TBARS), and reduced GSH content, and impaired short-term memory and motor coordination.ResultsPre-treatment with standardized ethyl acetate extract of Ocimum basilicum (100 and 200Â mg/kg, p.o.) markedly reduced cerebral infarct size and lipid peroxidation, restored GSH content, and attenuated impairment in short-term memory and motor coordination.ConclusionThe results of the study suggest that Ocimum basilicum could be useful clinically in the prevention of stroke.
Global cerebral ischemia and reperfusion-induced cerebral damage as well as motor dysfunctions were significantly attenuated by pretreatment with the ethyl acetate extract of Ocimum basilicum (100Â mg/kg and 200Â mg/kg, p.o.). Thus Ocimum basilicum could be useful clinically in the prevention of stroke.151
Journal: Journal of Ethnopharmacology - Volume 137, Issue 3, 11 October 2011, Pages 1360-1365