کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5840333 | 1124009 | 2011 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Suppressive effects of YiGanKang, a combination of Chinese herbs, on collagen synthesis in hepatic stellate cell
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موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Suppressive effects of YiGanKang, a combination of Chinese herbs, on collagen synthesis in hepatic stellate cell Suppressive effects of YiGanKang, a combination of Chinese herbs, on collagen synthesis in hepatic stellate cell](/preview/png/5840333.png)
چکیده انگلیسی
Background/AimClinical practice and animal research demonstrated that YiGanKang, a combination of Chinese herbs, has anti-fibrosis effects in chronic liver diseases. However, the mechanism is not clear. The present study is to investigate the inhibiting mechanism of YiGanKang on collagen type I synthesis induced by Interleukin-1β(IL-1 β) in rat hepatic stellate cells (HSCs).MethodsCultured rat HSCs were divided into 4 groups, control, IL-1β treated group, IL-1β + YiGanKang group and IL-1β + SB203580 (the p38 mitogen-activated protein kinase inhibitor) treated group. The expression of p38 mitogen-activated protein kinase (p38 MAPK), was evaluated by Western blot, collagen type I synthesis was examined by 3H-Pro incorporation.ResultsType I collagen synthesis in HSCs increased significantly under the stimulation of IL-1β for 24 h, YiGanKang could inhibit p38 expression and type I collagen synthesis, SB203580, a p38 inhibitor, can significantly reduce type I collagen synthesis.ConclusionIL-1β could stimulate the synthesis of type I collagen in rat HSCs, p38 mediate signal pathway between IL-1β and was type I collagen production. YiGanKang inhibits HSCs collagen synthesis induced by IL-1β via p38 inhibition.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Ethnopharmacology - Volume 134, Issue 3, 12 April 2011, Pages 949-952
Journal: Journal of Ethnopharmacology - Volume 134, Issue 3, 12 April 2011, Pages 949-952
نویسندگان
Yaping Zhang, Xixian Yao,