کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5843387 | 1560868 | 2013 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
ADAM17, shedding, TACE as therapeutic targets
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کلمات کلیدی
EGFERKgp130PMA - LDC هاADAM - آدامinterleukin - اینترلوکینa disintegrin and metalloprotease - تخریب و متالوپروتئازepidermal growth factor - عامل رشد اپیدرمیmitogen-activated protein kinase - پروتئین کیناز فعال با mitogenMAP kinase - کیناز MAPextracellular signal-regulated kinase - کیناز تنظیم شده سیگنال خارج سلولی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: ADAM17, shedding, TACE as therapeutic targets ADAM17, shedding, TACE as therapeutic targets](/preview/png/5843387.png)
چکیده انگلیسی
ADAM17 has been molecularly cloned as the enzyme responsible for cleavage of the transmembrane protein TNFα (TNFα converting enzyme, TACE). Later it was realized that ADAM17 was also responsible for the processing of cell adhesion proteins, cytokine and growth factor receptors and many ligands of the EGF receptor. Since TNFα is a target of anti-inflammatory therapies, it was speculated that inhibition of ADAM17 might be a therapeutic strategy in the treatment of inflammation or inflammation associated cancer. Meanwhile it has been recognized that ADAM17 governs many vital functions in the body and loss of ADAM17 leads to severe defects in the skin and to high susceptibility of the intestine to inflammation. Here I summarize data on the physiologic role of ADAM17 and the feasibility of specific blockade of this enzyme.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacological Research - Volume 71, May 2013, Pages 19-22
Journal: Pharmacological Research - Volume 71, May 2013, Pages 19-22
نویسندگان
Stefan Rose-John,