Neuropeptide S inhibits stress-stimulated faecal output in the rat

- The central NPS-NPSR system plays no apparent role in normal GI motility.
- Central NPS inhibits colonic motility, affecting the stress-stimulated defecation in rats.
- The ability of NPS to inhibit stress-stimulated faecal output together with its anxiolytic effect is promising, IBS patients where the hyperactivity of the CRF system contributes to the co-morbidity of anxiety with colonic motor symptoms.