Vaspin prevents TNF-α-induced intracellular adhesion molecule-1 via inhibiting reactive oxygen species-dependent NF-κB and PKCθ activation in cultured rat vascular smooth muscle cells

► Effect of vaspin on TNF-α-induced inflammation in vascular SMCs was examined. ► Vaspin inhibits TNF-induced monocyte adhesion to SMCs. ► Vaspin limits ICAM-1 induction by inhibiting ROS-mediated NF-κB and PKCθ activation. ► In conclusion, vaspin could play an inhibitory role on vascular SMCs inflammation.