کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5844080 1127528 2012 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Associate Editor: I. KimuraChallenges to congenital genetic disorders with “RNA-targeting” chemical compounds
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Associate Editor: I. KimuraChallenges to congenital genetic disorders with “RNA-targeting” chemical compounds
چکیده انگلیسی

Patients of congenital diseases such as Down syndrome (DS) and Duchenne muscular dystrophy (DMD) have abnormalities in their chromosomes and/or genes. Therefore, it has been considered that drug treatments can serve to do little for these patients more than to patch over each symptom temporarily when it arises. Although we cannot normalize their chromosomes and genes with chemical drugs, we may be able to manipulate the amounts and patterns of mRNAs transcribed from patients' DNAs with small chemicals. Based on this simple idea, we have looked for chemical compounds which can be applicable for congenital diseases and found that protein kinase inhibitors such as INDY, TG003, and SRPIN340 are promising as clinical drugs for DS, DMD, and DDS, respectively.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology & Therapeutics - Volume 134, Issue 3, June 2012, Pages 298-305
نویسندگان
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