کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5845745 1128307 2014 29 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
5-Aminosalicylic Acid attenuates allergen-induced airway inflammation and oxidative stress in asthma
ترجمه فارسی عنوان
اسید 5-آمینوسالسیلیک اسید باعث کاهش التهاب هوای آلرژیک و استرس اکسیداتیو در آسم می شود
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی ریوی و تنفسی
چکیده انگلیسی
Pro-inflammatory cytokines regulate the magnitude of allergic reactions during asthma. Tumor necrosis factor - alpha (TNF-α), interleukin-6 (IL-6) and interleukin-13 (IL-13) play a crucial role in aggravating the inflammatory conditions during allergic asthma. In addition, oxidative stress contributes to the pathogenesis of asthma by altering the physiological condition resulting in the development of status asthmaticus. Anti-inflammatory corticosteroids are being widely used for treating allergic asthma. In the present study 5-aminosalicylic acid (5-ASA), a salicylic acid derivative, was evaluated, in vivo for its potential to suppress TNF-α, IL-6 and IL-13 using ovalbumin (OVA) induced allergic asthma in Balb/C mice. Oral administration of 65, 130 and 195 mg/kg 5-ASA significantly reduced the OVA induced total and differential leucocyte count, TNF-α, IL-6, IL-13, nitrite, nitrate, MDA, MPO and TPL levels in the lung lavage samples. Collectively, these findings suggest that 5-ASA is a potent immunomodulator and suppresses key Th2 cytokines production and oxidative stress in OVA-induced asthma.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pulmonary Pharmacology & Therapeutics - Volume 29, Issue 2, December 2014, Pages 209-216
نویسندگان
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