کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5846164 | 1128456 | 2015 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Early life exposure to allergen and ozone results in altered development in adolescent rhesus macaque lungs
ترجمه فارسی عنوان
قرار گرفتن در معرض ابتلا به آلرژن و ازن باعث ایجاد تغییر در ریه های رایس ماکائو می شود
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کلمات کلیدی
HDMAHDMVNPA/P - A / PAsthma - آسمHouse dust mite allergen - آلرژن گرد و غبار خانهalveoli - آلوئولStereology - استریولوژیOzone - اُزون volume density - تراکم حجمLung development - توسعه ریهVias - جاده هاIslands - جزایرintravenously - داخل وریدیIntramuscular - عضلانیfiltered air - هوا فیلتر شده استBridges - پل هاVAD - چهHouse dust mite - گرد و غبار خانه
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
In rhesus macaques, previous studies have shown that episodic exposure to allergen alone or combined with ozone inhalation during the first 6Â months of life results in a condition with many of the hallmarks of asthma. This exposure regimen results in altered development of the distal airways and parenchyma (Avdalovic et al., 2012). We hypothesized that the observed alterations in the lung parenchyma would be permanent following a long-term recovery in filtered air (FA) housing. Forty-eight infant rhesus macaques (30Â days old) sensitized to house dust mite (HDM) were treated with two week cycles of FA, house dust mite allergen (HDMA), ozone (O3) or HDMA/ozone (HDMAÂ +Â O3) for five months. At the end of the five months, six animals from each group were necropsied. The other six animals in each group were allowed to recover in FA for 30 more months at which time they were necropsied. Design-based stereology was used to estimate volumes of lung components, number of alveoli, size of alveoli, distribution of alveolar volumes, interalveolar capillary density. After 30Â months of recovery, monkeys exposed to HDMA, in either group, had significantly more alveoli than filtered air. These alveoli also had higher capillary densities as compared with FA controls. These results indicate that early life exposure to HDMA alone or HDMAÂ +Â O3 alters the development process in the lung alveoli.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology and Applied Pharmacology - Volume 283, Issue 1, 15 February 2015, Pages 35-41
Journal: Toxicology and Applied Pharmacology - Volume 283, Issue 1, 15 February 2015, Pages 35-41
نویسندگان
M.J. Herring, L.F. Putney, J.A. St. George, M.V. Avdalovic, E.S. Schelegle, L.A. Miller, D.M. Hyde,