PCB153 reduces telomerase activity and telomere length in immortalized human skin keratinocytes (HaCaT) but not in human foreskin keratinocytes (NFK)

► Human immortal (HaCaT) and primary (NFK) keratinocytes were exposed to PCB153. ► PCB153 significantly reduced telomerase activity and telomere length in HaCaT. ► No effect on telomere length and telomerase activity was found in NFK. ► Increased intracellular superoxide levels and reduced cell growth was seen in both. ► PCB153 may damage telomerase expressing cells like stem cells.