Fibrin(ogen)olytic activity of bumblebee venom serine protease

► Bumblebee venom serine protease (Bt-VSP) is a fibrin(ogen)olytic enzyme. ► Bt-VSP activates prothrombin. ► Bt-VSP directly degrades fibrinogen into fibrin degradation products. ► Bt-VSP is a hemostatically active protein that is a potent clinical agent.