کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5847040 | 1129309 | 2015 | 18 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
FDA-approved small-molecule kinase inhibitors
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
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چکیده انگلیسی
Kinases have emerged as one of the most intensively pursued targets in current pharmacological research, especially for cancer, due to their critical roles in cellular signaling. To date, the US FDA has approved 28 small-molecule kinase inhibitors, half of which were approved in the past 3 years. While the clinical data of these approved molecules are widely presented and structure-activity relationship (SAR) has been reported for individual molecules, an updated review that analyzes all approved molecules and summarizes current achievements and trends in the field has yet to be found. Here we present all approved small-molecule kinase inhibitors with an emphasis on binding mechanism and structural features, summarize current challenges, and discuss future directions in this field.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Trends in Pharmacological Sciences - Volume 36, Issue 7, July 2015, Pages 422-439
Journal: Trends in Pharmacological Sciences - Volume 36, Issue 7, July 2015, Pages 422-439
نویسندگان
Peng Wu, Thomas E. Nielsen, Mads H. Clausen,