کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5847066 | 1129350 | 2013 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Gold-nanoparticle-based biosensors for detection of enzyme activity
ترجمه فارسی عنوان
طیف سنجی بیوسیانسورهای مبتنی بر نانوذرات برای تشخیص فعالیت آنزیم
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
چکیده انگلیسی
Optimal enzyme activity is essential for maintenance of physiological homeostasis. A variety of both non-genetic and genetic disruptions can excessively activate or silence intrinsic enzyme activities, with pathological outcomes. Many pharmacological agents are activators and inhibitors of enzymes. It is essential, therefore, in the development of drugs as enzyme activators and inhibitors, that enzyme activities be accurately measured under physiological and pathological conditions. Different biochemical assays have been developed for this purpose, some of which are based on nanostructured materials. This review focuses on gold nanoparticle (GNP)-based structures for the sensing and measurement of enzyme activities in biological specimens. Here we provide an overview and critical analysis of such assays, identify their advantages and limitations, and discuss interesting features of GNPs to be exploited for future applications in pharmacology.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Trends in Pharmacological Sciences - Volume 34, Issue 9, September 2013, Pages 497-507
Journal: Trends in Pharmacological Sciences - Volume 34, Issue 9, September 2013, Pages 497-507
نویسندگان
Eliza Hutter, Dusica Maysinger,